The Value of Haplotyping
AbstractThe relevant unit of inheritance is not the allele but the ancestral haplotype. These sequences are inherited faithfully over thousands of generations. We have developed haplospecific markers for a region of Bota Chromosome 19 which influences fat metabolism. Haplotypes were identified by family segregation. Comparing haplotype frequencies between Wagyu, Angus and Simmental reveals breed specific ancestral haplotypes which allow the majority of Wagyu to be distinguished from Angus masquerading as Wagyu. Breed specific haplotypes are associated with traits characteristic of a breed. These haplotypes can then be used for marker assisted selection to increase favorable characteristics within a breed or to blend desired characteristics from different breeds.
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